Table 2 Reported mutations in the PBP1A binding site and tunnel-1 residues of AMX-resistant and susceptible strains
| Mutations | Binding site | Tunnel-1 |
No of strains R1/S2 | Ref |
|---|---|---|---|---|
| Ala369Thr | ✓ | ✓ | 3/4R–0/12S | [28] |
| Thr541Ilu | ✓ | – | 1/3R–0/9S | [18] |
| Asn560Thr | ✓ | ✓ | 1/4R–0/5S | [23] |
| Thr556Ser | ✓ | – | 8/12R–0/19S |
[16] [18] [23] [29] This study |
| Phe366Leu | – | ✓ | 7/7R | [15] |
| Ser414Arg | ✓ | ✓ | 31/104R–1/106S |
[15] [18] [22] [28] [39] This study |
| Val469Met | – | ✓ | 2/5R–0/11S |
[24] This study |