Table 1 Detected mutations in the PBP1A drug binding site and tunnel-1 residues of AMX- resistant and susceptible strains
| Strains | Binding site | Tunnel-1 | MIC (mg/L) |
|---|---|---|---|
| Ref | |||
| J99 | – | – | S |
| 26,695 | – | – | S |
| Sensitive | |||
| MK984227 | – | – | 0.064 |
| MK984220 | – | – | 0.064 |
| MK984215 | – | – | 0.094 |
| MK984213 | – | – | 0.125 |
| MK984219 | – | – | 0.125 |
| MK984223 | – | – | 0.125 |
| MK984221 | – | – | 0.125 |
| MK984226 | – | – | 0.094 |
| MK984225 | – | – | 0.032 |
| MK984214 | – | – | 0.125 |
| Resistant | |||
| MK984217 | – | – | 0.38 |
| MK984216 | – |
Ser414Arg Val469Met | 0.5 |
| MK984218 | Thr556Ser | Ser414Arg | 0.38 |
| MK984224 | – | – | 0.75 |